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Graham StarTox™ Suite of Software

The Graham StarTox™ Suite of software for toxicology  and pathology laboratories was developed by Roger S. Graham of Graham Laboratories with the collaboration of the principals of Druquest.  Following the death of Mr. Graham, Druquest is continuing the development, marketing and maintenance of this remarkable software.

Modules of the Suite for Necropsy and Histopathology have been completed and have been in use since 2002.  Modules for in-life observations and organ weights are under development and will be released in 2014.  An add-on side labeling module is available as well as bespoke clinical pathology software.  These database programs are used to collect data from preclinical toxicology studies and produce detailed as well as summary reports suitable for inclusion in IND and NDA submissions.

The software is compliant with GLP requirements and can be implemented in compliance with Part 11 for electronic records.  The current version of the histopathology module has been updated to provide two audit trails; one an event logger and the other a study specific audit trail of all data entries and deletions; all time, date, pathologist and computer identified.  The data input can be locked and requires a password and reason for unlocking.  All changes following unlocking are recorded in the audit trail.

The StarTox Suite operates on PCs running WindowsXP, Vista, Windows 7 or Windows 8 operating systems.  The software is written Visual Basic 6.0 using Microsoft Access as the database.  Seperate licenses for Microsoft Access, Microsoft Outlook and a PDF writer are required.  StarTox will run on a stand-alone PC or on multiple PCs accessing a network database.

                                                    input                      report

                   Check the left image for an image of data input screen, right image for report setup screen

The first module, StarPath, was originally developed in 1983 by Toad Hall Systems, Inc. (now reorganized as Druquest International, Inc.)  It was developed in Dartmouth Basic language running on a CPM operating system.  Graham Laboratoreis in collaboration with Druquest continued development of StarPath on IBM compatible PCs with the MS-DOS operating system. Starpath was rewritten in Microsoft QuickBasic and the first DOS system was released in 1985.  Since that time the system has been continuously upgraded and a Windows version was released in 2002.  During its development history, the system has been in use by more than 20 laboratories.  It has survived the test of time and service.